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 Alveolar soft part sarcoma (ASPS) is an exceptionally rare nonrhabdomyosarcomatous soft tissue sarcoma (NRSTS), characterized by the translocation t(X;17) p(112;q25) This translocation results in the chimeric ASPSCR1TF transcription factor Plasmid construction Nterminal FLAGtagged ASPSCR1TF was introduced into both the pMYsIRESGFP and pMYsIRESLuc vectors The fulllength ASPSCR1TF was cloned from a human ASPS case Artificial chimeric ASPSCR1 fusions between ASPSCR1 and TFEB, TFEC, or MITF were also generated by twostep PCR using primers encompassing both ASPSCR1 andOur results demonstrate that the most sensitive marker of alveolar soft part sarcoma was the presence of the ASPSCR1TF fusion transcript Thus, detection of the ASPSCR1TF fusion transcript was considered applicable for formalinfixed, paraffinembedded tissues with superior sensitivity as compared with TF immunohistochemical staining

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Aspscr1

Aspscr1-The RNAsequencing results generated in the HPA are reported as normalized NX values In the Human Protein Atlas a NX value of 10 is defined as a threshhold for expression of the corresponding protein The cell lines are divided into colorcoded groups according to their origin in the human body31 ASPSCR1 Silencer Select Predesigned, Validated, and Custom siRNA in Standard, HPLC, and Invivo Ready Purities

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ASPSCR1 (ASPL, ASPS, TUG, UBXD9, UBXN9) Tissue specificityi The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5 The categories include tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detectedASPSCR1 gene product ASPL, ASPS, TUG, UBXD9, UBXN9 The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4) This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membraneASPSCR1 A gene on chromosome 17q253 that encodes a ubiquitous tethering protein highly expressed in the testes, heart, skeletal muscle and pancreas;

The most common fusion partners are the papillary renal cell carcinoma (PRCC, 1q21) gene and alveolar soft part sarcoma chromosome region, candidate 1 (ASPSCR1, 17q25) geneBioGRID Interaction Between ASPSCR1 And VCP Toggle navigation Bio GRID 44ASPSCR1 Explore an overview of ASPSCR1, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data

AceView offers a comprehensive annotation of human, mouse and nematode genes reconstructed by coalignment and clustering of all publicly available mRNAs and ESTs on the genome sequence Our goals are to offer a reliable uptodate resource on the genes, their functions, alternative variants, expression, regulation and interactions, in the hope to stimulate further validatingASPSCR1 Human Recombinant produced in E coli is a single polypeptide chain containing 576 amino acids (1553) and having a molecular mass of 626kDa ASPSCR1 is fused to a 23 amino acid Histag at Nterminus & purified by proprietary chromatographic techniquesASPSCR1 (Alveolar soft part sarcoma critical region 1) alveolar soft part sarcoma chromosome region, candidate 1 Starts at and ends at bp from pter ( according to GRCh38/hg38Dec_13) Mapping ASPSCR1png alternative splicing of 47 bp from exon 2 in the 5' untranslated region 476 amino acids;

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Summaries for ASPSCR1 gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/SwissProt,3 ASPSCR1 TEXT A number sign (#) is used with this entry because some cases of alveolar soft part sarcoma have been found to be caused by fusion of the ASPSCR1 () and TF () genes Description Alveolar soft part sarcoma is an unusual tumor with highly characteristic histopathology and ultrastructureCreative diagnostics provides ASPSCR1 antibodies and elisa kits for science research use, feel free to contact us

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Other interactions of ASPSCR1 The der (17)t (X;17) (p11;q25) of human alveolar soft part sarcoma fuses the TF transcription factor gene to ASPL, a novel gene at 17q25 8 The status of the TP53 alleles was followed at different stages by fluorescence in situ hybridization (FISH) and allelespecific PCR ( ASPCR) on total DNA, as well as flow ASPSCR1TF fusion and several somatic copy number alterations, including the loss of 22q, are associated with aggressive features and poor outcomes Apart from tumors with MED15TF fusionASPSCR1 tether for SLC2, UBX domain containing Aliases TUG, ASPL, ASPS, RCC17, UBXD9, UBXN9, ASPCR1 Location 17q253 Summary The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4) This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle

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Aims Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumour with unique morphology and a recurrent, nonreciprocal translocation der(17)t(X;17)(p112;q25) leading to the fusion of ASPSCR1 (also known as ASPL) to the transcription factor TF Although diagnosis is straightforward in classical cases, tumours with atypical morphological features may be difficult to classify solely onASPSCR1 synonyms, ASPSCR1 pronunciation, ASPSCR1 translation, English dictionary definition of ASPSCR1 v tugged , tug·ging , tugs v tr 1 To pull at vigorously or repeatedly tugged the bell rope See Synonyms at pull 2 To move by pulling with greatSymbol Description Category GIFtS GC id Score;

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ASPSCR1 has several biochemical functions, for example, molecular_function, protein binding Some of the functions are cooperated with other proteins, some of the functions could acted by ASPSCR1 itself We selected most functions ASPSCR1 had, and list some proteins which have the same functions with ASPSCR1Use BioRad's PrimePCR assays, controls, templates for your target gene Every primer pair is optimized, experimentally validated, and performance guaranteedCreative diagnostics provides ASPSCR1 antibodies and elisa kits for science research use, feel free to contact us

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Contains an UBX domain, which ASPL is a cofactor of the hexameric ATPase complex, known as p97 The central area in ASPL, containing both a SHP box and a UBX domain, is required for binding to the p97 Ndomain Results support a gainoffunction role for ASPSCR1TF contributing to proliferation and survival of cancer cells Promotes methylation of VCP by METTL21D ASPSCR1 expression was also found in all cancer cell lines tested Independently, Heimann et al (01) identified the ASPSCR1 gene, which they called RCC17, partnered with TF in two 5yearold Belgian girls of African origin in whom papillary renal cell carcinomas () carried the translocation t(X;17)(p112;q25)

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ASPSCR1 is altered in 011% of all cancers with alveolar soft part sarcoma, translocationassociated renal cell carcinoma, high grade ovarian serous adenocarcinoma, endometrial endometrioid adenocarcinoma, and unknown having the greatest prevalence of alterationsASPSCR1 (arrow) was detected using the purified antibody ASPSCR1 Antibody flow cytometry of HeLa cells (right histogram) compared to a negative control cell (left histogram) FITCconjugated goatantirabbit secondary antibodies were used for the analysis The ASPSCR1TF and ASPSCR1TFEB but not ASPSCR1TFEC and ASPSCR1MITF induced sarcoma The results suggest the presence of TF/TFEBspecific cofactors and mechanisms for tumorigenesis In order to identify such novel cofactors and functional motifs, human ASPS cellnuclear extract was incubated with TF or MITF proteins and TF or MITF

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ASPSCR1 Name ASPSCR1 tether for SLC2, UBX domain containing Synonyms A A306_ alveolar soft part sarcoma chromosomal region candidate gene 1 protein alveolar soft part sarcoma chromosomal region candidate gene 1 proteinCreative Biolabs can provide AntiASPSCR1 Aptamer Complement Function/Activity Test Complement function or activity test allows for the determination of whether the protein is present and whether it has normal functional activity A wide range of assays are now available in Creative Biolabs, such as Hemolysis assays (CH50 or AH50), ElisaDisease ASPSCR1/TF renal cell carcinomas harbor the same gene fusion as alveolar soft part sarcoma, but belong to the family of Xp11 translocation RCC Xp11 translocation renal cell carcinoma (RCCs) harbor gene fusions involving TF transcription factor The The t (6;11) RCCs harbor a specific MALAT1 (Alpha) TFEB gene fusion

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Functional Associations ASPSCR1 has 4,6 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 77 datasetsOncoKB is a precision oncology knowledge base developed at Memorial Sloan Kettering Cancer Center that contains biological and clinical information about genomic alterations in cancerImmunoprecipitation analysis of 0ug extracts of A549 cells, using 3 ug TUG/ASPSCR1 antibody (481) Western blot was performed from the immunoprecipitate using TUG/ASPSCR1 antibody (481) at a dilition of Immunohistochemistry of paraffinembedded rat kidney using TUG/ASPSCR1 antibody (481) at dilution of 1100 (40x lens)

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1 ASPSCR1 ASPSCR1 Tether For SLC2, UBX Domain Containing Protein Coding 41 GC17P 47 2 TF Transcription Factor Binding To IGHM Enhancer 3View mouse Aspscr1 Chr with phenotypes, sequences, polymorphisms, proteins, references, function, expression ASPSCR1 (ASPSCR1 Tether For SLC2, UBX Domain Containing) is a Protein Coding gene Diseases associated with ASPSCR1 include Alveolar Soft Part Sarcoma and Renal Cell Carcinoma, Xp11AssociatedAmong its related pathways are Vesiclemediated transport and Translocation of GLUT4 to the plasma membraneAn important paralog of this gene is UBXN6

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It sequesters GLUT4containing vesicles in the cytoplasm in absence of insulinSynonyms for ASPSCR1 in Free Thesaurus Antonyms for ASPSCR1 54 synonyms for tug pull, drag, pluck, jerk, yank, wrench, lug, drag, pull, haul, tow, lug, heave, drawSequence variants and/or copy number variants (deletions/duplications) within the ASPSCR1 gene will be detected with >99% sensitivity Variants classified as unknown significance (VUS), likely pathogenic, or pathogenic will be reported Benign and li

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VCP ASPSCR1 Affinity CaptureLuminescence Affinity CaptureLuminescence An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag ASPSCR1 470 Annotation score Annotation score1 out of 5 The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome This score cannot be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given proteinASPSCR1, UBX domain containing tether for SLC2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17ї хромосоми Довжина поліпептидного ланцюга білка становить 553 амінокислот

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AntiASPSCR1 antibody (Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1) Primary Antibody ASPSCR1 Reactivity Human, Mouse, Rat IF, IHC, WB Host Rabbit Polyclonal unconjugated camera_alt 4Aspscr1 ID ZDBGENE Name ASPSCR1 tether for SLC2, UBX domain containing Symbol aspscr1 Nomenclature History Previous Names zgc;Description Homo sapiens ASPSCR1 tether for SLC2, UBX domain containing (ASPSCR1), transcript variant 2, mRNA (from RefSeq NM_) RefSeq Summary (NM_) The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4) This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle

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 Aspscr1 2 Annotation score Annotation score1 out of 5 The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome This score cannot be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein

T X 17 Tfe Aspscr1 Alveolar Soft Part Sarcoma Great Link To Patient Focused Page Sarcoma Molecular Genetics Pathology

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