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 Alveolar soft part sarcoma (ASPS) is an exceptionally rare nonrhabdomyosarcomatous soft tissue sarcoma (NRSTS), characterized by the translocation t(X;17) p(112;q25) This translocation results in the chimeric ASPSCR1TF transcription factor Plasmid construction Nterminal FLAGtagged ASPSCR1TF was introduced into both the pMYsIRESGFP and pMYsIRESLuc vectors The fulllength ASPSCR1TF was cloned from a human ASPS case Artificial chimeric ASPSCR1 fusions between ASPSCR1 and TFEB, TFEC, or MITF were also generated by twostep PCR using primers encompassing both ASPSCR1 andOur results demonstrate that the most sensitive marker of alveolar soft part sarcoma was the presence of the ASPSCR1TF fusion transcript Thus, detection of the ASPSCR1TF fusion transcript was considered applicable for formalinfixed, paraffinembedded tissues with superior sensitivity as compared with TF immunohistochemical staining

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Aspscr1

Aspscr1-The RNAsequencing results generated in the HPA are reported as normalized NX values In the Human Protein Atlas a NX value of 10 is defined as a threshhold for expression of the corresponding protein The cell lines are divided into colorcoded groups according to their origin in the human body31 ASPSCR1 Silencer Select Predesigned, Validated, and Custom siRNA in Standard, HPLC, and Invivo Ready Purities

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ASPSCR1 (ASPL, ASPS, TUG, UBXD9, UBXN9) Tissue specificityi The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5 The categories include tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detectedASPSCR1 gene product ASPL, ASPS, TUG, UBXD9, UBXN9 The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4) This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membraneASPSCR1 A gene on chromosome 17q253 that encodes a ubiquitous tethering protein highly expressed in the testes, heart, skeletal muscle and pancreas;

The most common fusion partners are the papillary renal cell carcinoma (PRCC, 1q21) gene and alveolar soft part sarcoma chromosome region, candidate 1 (ASPSCR1, 17q25) geneBioGRID Interaction Between ASPSCR1 And VCP Toggle navigation Bio GRID 44ASPSCR1 Explore an overview of ASPSCR1, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data

AceView offers a comprehensive annotation of human, mouse and nematode genes reconstructed by coalignment and clustering of all publicly available mRNAs and ESTs on the genome sequence Our goals are to offer a reliable uptodate resource on the genes, their functions, alternative variants, expression, regulation and interactions, in the hope to stimulate further validatingASPSCR1 Human Recombinant produced in E coli is a single polypeptide chain containing 576 amino acids (1553) and having a molecular mass of 626kDa ASPSCR1 is fused to a 23 amino acid Histag at Nterminus & purified by proprietary chromatographic techniquesASPSCR1 (Alveolar soft part sarcoma critical region 1) alveolar soft part sarcoma chromosome region, candidate 1 Starts at and ends at bp from pter ( according to GRCh38/hg38Dec_13) Mapping ASPSCR1png alternative splicing of 47 bp from exon 2 in the 5' untranslated region 476 amino acids;

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Summaries for ASPSCR1 gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/SwissProt,3 ASPSCR1 TEXT A number sign (#) is used with this entry because some cases of alveolar soft part sarcoma have been found to be caused by fusion of the ASPSCR1 () and TF () genes Description Alveolar soft part sarcoma is an unusual tumor with highly characteristic histopathology and ultrastructureCreative diagnostics provides ASPSCR1 antibodies and elisa kits for science research use, feel free to contact us

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Other interactions of ASPSCR1 The der (17)t (X;17) (p11;q25) of human alveolar soft part sarcoma fuses the TF transcription factor gene to ASPL, a novel gene at 17q25 8 The status of the TP53 alleles was followed at different stages by fluorescence in situ hybridization (FISH) and allelespecific PCR ( ASPCR) on total DNA, as well as flow ASPSCR1TF fusion and several somatic copy number alterations, including the loss of 22q, are associated with aggressive features and poor outcomes Apart from tumors with MED15TF fusionASPSCR1 tether for SLC2, UBX domain containing Aliases TUG, ASPL, ASPS, RCC17, UBXD9, UBXN9, ASPCR1 Location 17q253 Summary The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4) This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle

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Aims Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumour with unique morphology and a recurrent, nonreciprocal translocation der(17)t(X;17)(p112;q25) leading to the fusion of ASPSCR1 (also known as ASPL) to the transcription factor TF Although diagnosis is straightforward in classical cases, tumours with atypical morphological features may be difficult to classify solely onASPSCR1 synonyms, ASPSCR1 pronunciation, ASPSCR1 translation, English dictionary definition of ASPSCR1 v tugged , tug·ging , tugs v tr 1 To pull at vigorously or repeatedly tugged the bell rope See Synonyms at pull 2 To move by pulling with greatSymbol Description Category GIFtS GC id Score;

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ASPSCR1 has several biochemical functions, for example, molecular_function, protein binding Some of the functions are cooperated with other proteins, some of the functions could acted by ASPSCR1 itself We selected most functions ASPSCR1 had, and list some proteins which have the same functions with ASPSCR1Use BioRad's PrimePCR assays, controls, templates for your target gene Every primer pair is optimized, experimentally validated, and performance guaranteedCreative diagnostics provides ASPSCR1 antibodies and elisa kits for science research use, feel free to contact us

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